The Pagán Lab
We are interested in the regulation of immunity and pathogenesis in tuberculosis (TB). TB is characterized by the formation of multicellular aggregates of immune cells called granulomas. We leverage the powerful genetics and imaging capabilities of genetically diverse fish models of TB, which capture key features of human TB granulomas, to address fundamental questions in mycobacterial pathogenesis and granuloma immunobiology.
Mycobacterium marinum granuloma in a zebrafish larva with fluorescently labeled mycobacteria and macrophages.